Mekanisme Resistensi Isoniazid &Mutasi Gen KatG Ser315Thr (G944C) Mycobacterium tuberculosis Sebagai Penyebab TerseringResistensi Isoniazid

Authors

  • Mara Imam Taufiq Siregar FKIK UNJA

DOI:

https://doi.org/10.22437/jmj.v3i2.3088

Abstract

ABSTRACT

Resistance to anti-tuberculosis drugs mainly occurs due to a mutation in the genes of Mycobacterium tuberculosis. Mutations can be induced by inadequate therapeutic levels of drug, mainly due to non-compliance for taking the drug. Therefore, the use of anti-tuberculosis drugs inappropriately and irregularly can lead to mutation in the gene encoding the target of anti-tuberculosis drugs. Inadequate therapeutic levels of drug due to non-compliance of patients taking isoniazid was the most frequent causing mutations in  KatG (Ser315Thr) gene. Therefore, concluded that this mutation was the commonest cause of INH resistance and could be a potential genetic marker for predicting MDR-TB.

 

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Author Biography

Mara Imam Taufiq Siregar, FKIK UNJA

Bagian Farmakologi & Terapi Fakultas Kedokteran dan Ilmu Kesehatan Universitas Jambi

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How to Cite

Taufiq Siregar, M. I. (2015). Mekanisme Resistensi Isoniazid &Mutasi Gen KatG Ser315Thr (G944C) Mycobacterium tuberculosis Sebagai Penyebab TerseringResistensi Isoniazid. Jambi Medical Journal : Jurnal Kedokteran Dan Kesehatan, 3(2). https://doi.org/10.22437/jmj.v3i2.3088