Alternate Day Fasting terhadap Berat Badan, dan Enzim Transaminase pada Tikus Putih Galur Sprague Dawley
DOI:
https://doi.org/10.22437/esehad.v5i1.35373Kata Kunci:
Obesitas, Alternate_Day_Fasting, berat_badan, SGOT, SGPT, Obesity, body_weightAbstrak
ABSTRAK
Latar Belakang Obesitas merupakan masalah epidemi global yang dapat meningkatkan risiko penyakit sindrom metabolik serta resistensi insulin. Modifikasi diet dan olahraga ringan dapat mengontrol metabolisme. Alternate Day Fasting merupakan salah satu modifikasi diet intermitten fasting dimana bergantian hari antara diet normal dan puasa. Ketika puasa dapat mengkonsumsi zat makanan 20-25% dari total energi. Tujuan penelitian untuk mengetahui pengaruh diet Alternate Day Fasting terhadap berat badan, dan fungsi hati . Metode penelitian ini merupakan penelitian eksperimental pada tikus jantan galur Sprague Dawley yang berumur 2-3 bulan, berat 150 – 250 gram, serta tidak ada kelainan anatomi, yang dibagi dalam 2 kelompok yakni kontrol (n=10) dan Alternate Day Fasting (n=10). Hasil penelitian diketahui Alternate Day Fasting dapat menurunkan berat badan (mean = 197,5) dibandingkan kontrol (mean = 253,6). Tidak terdapat perbedaan Serum Glutamic Oxaloacetate Transaminase (Mann Whitney; p>0.05), Serum Glutamic Pyruvic Transaminase (Mann Whitney; p>0.05) antara kelompok kontrol dan diet Alternate Day Fasting. Kesimpulan Diet Alternate Day Fasting dapat menurunkan berat badan, dan tidak mengakibatkan peningkatan Serum Glutamic Oxaloacetic Transaminase dan Serum Glutamic Pyruvic Transaminase.
Kata Kunci : Obesitas, Alternate_Day_Fasting, berat_badan, SGOT, SGPT
Unduhan
Referensi
Ganesan K., Habboush Y, Sultan S. Intermittent Fasting: The Choice for a Healthier Lifestyle. Cureus. . 2018;10(7). http://doi: 10.7759/cureus.2947.
Putri Andi Yusran Fadilah, Decroli Eva, Nasrul Ellyza. Hubungan Derajat Obesitas dengan Kadar Gula Darah Puasa Pada Masyarakat Di Kelurahan Batung Bata dan Kelurahan Korong Gadang, Kota Padang. Jurnal Kesehatan Andalas .2015;4(3):707–711.
Tinsley G M, La Bounty P M. Effects of intermittent fasting on body composition and clinical health markers in human, Nutrition Reviews. 2015;73(10): 661–674. http://doi: 10.1093/nutrit/nuv041.
St-Onge, M. P. et al. Meal Timing and Frequency: Implications for Cardiovascular Disease Prevention: A Scientific Statement from the American Heart Association, Circulation. 2017; 135(9):. e96–e121. http://doi: 10.1161/CIR.0000000000000476.
Stockman MC, Thomas D, Burke J, Apovian CM. Intermittent Fasting: Is the Wait Worth the Weight?". Current Obesity Reports (Review). 2018;7 (2): 172–185.
Patterson, R. E. et al. (5AD).Intermittent Fasting And Human Metabolic Health Ruth. J Acad Nutr Diet. 2017; 150(2):137–143.http:// doi: 10.1001/jamasurg.2014.1086.Feasibility.
Templeman, I. et al. Intermittent fasting, energy balance and associated health outcomes in adults: Study protocol for a randomised controlled trial’, Trials. Trials. 2018;19(1):1–11. http://doi: 10.1186/s13063-018-2451-8.
Jane, L. et al. Intermittent fasting interventions for the treatment of overweight and obesity in adults aged 18 years and over: a systematic review protocol. JBI database of systematic reviews and implementation reports. 2015;13(10):60–68. http://doi: 10.11124/jbisrir-2015-2363.
Vilar-Gomez, E. et al. Weight loss through lifestyle modification significantly reduces features of nonalcoholic steatohepatitis. Gastroenterology. 2015:149(2);. 367-378.e5. http://doi: 10.1053/j.gastro.2015.04.005.
Hall P, Cash J. What is the real function of the liver “function” tests?: Discovery Service for Endeavour College of Natural Health Library. Ulster Medical Journal, 2012;81(1):30–36. http:// www.ebscohost.com.
Alfin R, Busjra B, Azzam R. Pengaruh Puasa Ramadhan terhadap Kadar Gula Darah pada Pasien Diabetes Mellitus Tipe II. J Telenursing. 2019;1(1):191– 204.
Soeters MR, Lammers NM, Dubbelhuis PF, Ackermans MT, Jonkers-Schuitema CF, Fliers E, et al. Intermittent Fasting Does Not Affect Whole-body Glucose, Lipid, or Protein Metabolism. Am J Clin Nutr. 2009;90(5):1244–51.
Agung, A. et al. The Activities of Alanine Aminotransferase and Aspartate Aminotransferase Enzymes in Male White Rats Treated With Extract Areca Nut Treatment’, Buletin Veteriner Udayana.2017;9(2);132–138.http:// doi: 10.21531/bulvet.2017.9.2.132
