The Relationship Between Medical Treatment and Survival Rates Among Cervical Cancer Patients at Dr. M. Djamil General Hospital in Padang, 2020–2024

Authors

  • Pujatul Hasanah Master’s Program in Epidemiology, Faculty of Public Health, Andalas University, Padang, West Sumatra, Indonesia Author
  • Defriman Djafri Department of Public Health, Faculty of Public Health, Andalas University, Padang, West Sumatra, Indonesia Author
  • Yeffi Masnarivan Department of Public Health, Faculty of Public Health, Andalas University, Padang, West Sumatra, Indonesia Author
  • Syafrawati Syafrawati Department of Public Health, Faculty of Public Health, Andalas University, Padang, West Sumatra, Indonesia Author

DOI:

https://doi.org/10.22437/jkmj.v10i1.55320

Keywords:

Cervical Cancer, Medical Treatment, Radiotherapy, Stage, Survival

Abstract

Medical treatment for cervical cancer aims to improve survival, cure the disease, and prolong patients’ life expectancy. Cervical cancer treatment consists of surgery, radiation/radiotherapy, chemotherapy, or a combination of these three modalities, depending on the extent and stage of the disease. This study aims to analyze the relationship between medical treatment and the survival of cervical cancer patients at Dr. M. Djamil General Hospital, Padang, during the period 2020–2024. This study used a representative cohort design utilizing medical record data from Dr. M. Djamil General Hospital, Padang, of patients who underwent medical treatment from 2020 to 2024. Samples were selected using a simple random sampling technique, with a total of 121 samples. Data were analyzed through univariate, bivariate (Kaplan-Meier and Cox Regression), and multivariate. The results showed that among 121 patients, 57.0% underwent combination medical treatment. Based on patient characteristics, 90.9% were aged >35 years, 87.6% had an education level ≤ senior high school, 74.4% were unemployed, and 56.2% were in the advanced stage of disease. The association between type of medical treatment and survival showed a p-log rank value of 0.003 (<0.05), indicating that at least one type of medical treatment had a different survival outcome compared to the others. Based on survival analysis, a difference in survival was only found between radiotherapy and combination treatment. This study found differences among types of medical treatment in relation to the survival of cervical cancer patients.

References

1. Hasankhani MB, Jahani Y, Bazrafshan A, Yazdizadeh A, Karamoozian A. Factors Affecting Survival of Patients with Cervical Cancer. Iran J Public Health. 2023. 10:2216–24. https://doi.org/10.18502/ijph.v52i10.13860

2. Novalia V. (Cervical Cancer). Kanker serviks. GALENICAL: Jurnal Kedokteran dan Kesehatan Mahasiswa Malikussaleh. 2023. 2(1):45–56. https://doi.org/10.29103/jkkmm.v2i1.10134

3. World Health Organization. Cervical Cancer. 2024.

4. Li J, Liu G, Luo J, Yan S, Ye P, Wang J, et al. Cervical cancer prognosis and related risk factors for patients with cervical cancer: a long term retrospective cohort study. Vol. 1. 2022. 1(12:13994). https://doi.org/10.1038/s41598-022-17733-8

5. Bhatla N, Aoki D, Sharma DN, Sankaranarayanan R. Cancer of the cervix uteri: 2021 update. Int J Gynaecol Obstet. 2021. 155(1):28–44. https://doi.org/10.1002/ijgo.13865

6. Surmanto B, Alex M. Lumbanraja, Tengku Muhammad Fauzi. The Relationship Between Human Papillomavirus (HPV) Infection and Cervical Cancer Incidence. (Hubungan Infeksi Human Papillomavirus (HPV) dengan Kejadian Kanker Serviks). Jurnal Kedokteran Methodist. 2021. 14(2):1–8. https://ejurnalnew.methodist.ac.id/index.php/jkm/article/view/645

7. Mufarida A, et. al. Kaplan Meier Survival Curve Analysis Using Log Rank Test in Cervical Cancer Patients. (Analisis Kurva Survival Kaplan-Meier Menggunakan Uji Log Rank Pada Pasien Penyakit Kanker Serviks). Indonesian Council of Premier Statistical Science. 2023. 2(1):14–8. https://ejournal.uin-suska.ac.id/index.php/icopsic/article/view/25324

8. Teshome R, Yang I, Woldetsadik E, Girma E, Higgins M, Wells J. Survival Status and Predictors Among Women with Advanced Stage of Cervical Cancer. Int J Womens Health. 2024. 16:605–17. https://doi.org/10.2147/IJWH.S455235

9. Sharma S, Deep A, Sharma AK. Current Treatment for Cervical Cancer: An Update. Anticancer Agents Med Chem. 2020. 20(15):1768–79.

10. Cahayani RD, Jeniyanthi NPR, Devina Fikli. Analysis of Target Organ Doses and Organs at Risk in Brachytherapy for Endometrial Cancer Cases Using a Cylinder Applicator in the Radiotherapy Installation of Persahabatan Hospital (Analisis Dosis Organ Target dan Organ At Risk Pada Brakhiaterapi Kasus Kanker Endometrium Menggunakan Alat Aplikator Silinder Di Instalasi Radioterapi RSUP Persahabatan). Perpotif: Jurnal Kesehatan Masyarakat. 2024. 8(3):3852–64.

11. Kementerian Kesehatan Republik Indonesia. National Cancer Plan 2024-2034. (Rencana Kanker Nasional 2024-2034). Kementerian Kesehatan Republik Indonesia. 2024.

12. Winarno W. Cervical Cancer Radiotherapy with Linear Accelerator (LINAC). (Radioterapi Kanker Cervix dengan Linear Accelerator (LINAC)). Jurnal Biosains Pascasarjana. 2021. 23(2):75–86. https://doi.org/10.20473/jbp.v23i2.2021.75-86

13. Mayadev JS, Ke G, Mahantshetty U, Pereira MD, Tarnawski R, Toita T. Global challenges of radiotherapy for the treatment of locally advanced cervical cancer. Int J Gynecol Cancer. 2022. 32(3):436–45. https://doi.org/10.1136/ijgc-2021-003001

14. Warren MT, Galpin I, Bachtiger F, et. al. Ice Recrystallization Inhibition by Amino Acids: The Curious Case of Alpha- and Beta-Alanine. J Phys Chem Lett. 2022. 13(9):2237–44. https://doi.org/10.1021/acs.jpclett.1c04080

15. Tukan LAP, et al. Study of Chemotherapy Use in Cervical Cancer Patients at Dr. Ramelan Naval Hospital, Surabaya, 2024. 6(3):353–60.

16. Farma NA, Muhammad S, Asterina A. The Relationship between Age, Hemoglobin, and Body Mass Index with Changes in Tumor Size in Neoadjuvant Chemotherapy for Stage IB2 and IIA2 Cervical Cancer at Dr. M. Djamil Padang General Hospital. 2021. 2(1):62–9.

17. Putri DKF, Rena Oki Alestari, Angga Arsesiana. Treatment and Survival of Cervical Cancer Patients at the Dr. Doris Sylvanus Regional Public Service Agency in Palangka Raya in 2017. https://ojs.dinamikakesehatan.unism.ac.id/index.php/dksm/article/view/340

18. Kumala D, Arsesiana A. Determinants Related to the Survival of Cervical Cancer Patients at the Dr. Doris Sylvanus Regional Public Service Agency, Palangka Raya in 2018. https://doi.org/10.33859/psmumns.v0i1.20

19. Riyandianci N. Survival Analysis in Cervical Cancer Patients at Dr. Soetomo Regional Hospital, Surabaya Using Stratified Cox and Extended Cox. 2017. 10–2.

20. Anwari F, Charisma AM. The Relationship Between Knowledge Level and Cervical Cancer Prevention Measures After Counseling in Women of Childbearing Age.2017. 11–2.

21. Herniyatun, Lestyani, Kuntoadi GB, Karlina N, Dewi SU. Factors related to the incidence of cervical cancer. Ensiklopedia of Journal. 2024. 6(3):111–6.

22. Marina, Mevi AG. The Influence of Education and Attitudes of Women of Childbearing Age (WUS) on Knowledge of IVA Tests for Early Detection of Cervical Cancer in the PMB Novia Dewi Area.2025. 5(3):1260–7. https://doi.org/10.33024/mahesa.v5i3.16788

23. Naufaldi MD, Gunawan R, Halim R. Characteristics of Cervical Cancer Patients in Inpatients at Raden Mattaher Regional Hospital, Jambi, 2018-2020. 2022. 2(1):48–58. https://doi.org/10.22437/joms.v2i1.18092

24. Balaraj K, et.al. Clinical outcomes and treatment efficacy in cervical cancer patients in the UAE: a retrospective cohort study. Cureus. 2024. 16(7). https://doi.org/10.7759/cureus.64422

25. Tabatabaei FS, et.al. Evaluation of Survival Rate and Associated Factors in Patients with Cervical Cancer: A Retrospective Cohort Study. J Res Health Sci. 2022. 22(2). https://doi.org/10.34172/jrhs.2022.87

26. Daba E, Teshome D, Melaku T. Survival status and predictors among women with advanced stage of cervical cancer. Front Oncol. 2024. 14:1–12.

27. Otmani N, Hattad S. Clinical Outcome in Children with Chemotherapy-Induced Mucositis. Semin Oncol Nurs. 2021. 37(3):151–60. https://doi.org/10.1016/j.soncn.2021.151160

28. Zubaidah Z, et. al. The Three-Year Survival Rate Of Cervical Cancer Patients At Referral Hospital In Southern Sumatra, Indonesia. Jurnal Berkala Epidemiologi. 2022. 10(2):121–9.

29. Jayaraman S, Gunasekera S, Wijayaratne D, et al. Surgical outcomes in early-stage cervical cancer following radical hysterectomy in a resource-limited setting. BMC Cancer. 2023. 23. https://doi.org/10.7759/cureus.47744

30. Wright AGC, Ringwald WR. Personality disorders are dead; long live the interpersonal disorders: Comment on Widiger and Hines (2022). Personal Disord. 2022. 13(4):363–8. https://doi.org/10.1037/per0000552

31. Maharani A, et. al. Stage and Histopathology Type of Cervical Cancer in Cervical Cancer Patients with Chemoradiation at Abdoel Wahab Sjahranie Regional Hospital, Samarinda, 2021-2022. 2025. 7(3).

32. Harkenrider MM, et. al. Evaluation of surgical approaches and use of adjuvant radiotherapy with respect to oncologic outcomes in early-stage cervical carcinoma. Current Oncology. 2022. 29(10):7480–92. https://doi.org/10.3390/curroncol29120748

33. Moonmuang S, et. al. Circulating Long Non-Coding RNAs as Novel Potential Biomarkers for Osteogenic Sarcoma. Cancers (Basel). 2021;13(16). https://doi.org/10.3390/cancers13164214

34. Atasoy S, et. al. Generalized anxiety disorder symptoms and type 2 diabetes onset: Findings from the Prospective Cooperative Health Research in the Region of Augsburg F4 and FF4 studies. Psychosom Res. 2021. 145. https://doi.org/10.1016/j.jpsychores.2021.110480

35. Sagae S, Toita T, Matsuura M, et. al. Improvement in radiation techniques for locally advanced cervical cancer during the last two decades. Int J Gynecol Cancer 2023;33(8):1295–1303. 2023. 33(8):1295–303. https://doi.org/10.1136/ijgc-2022-004230

36. Trifanescu OG, Gales LN, et. al. Long-term oncological outcome in patients with cervical cancer after trimodality treatment. Medicine (Baltimore). 2021. 100(13). https://doi.org/10.1097/MD.0000000000025271

37. Chopra S, et. al. Late Toxicity After Adjuvant Conventional Radiation Versus Image-Guided Intensity-Modulated Radiotherapy for Cervical Cancer (PARCER): A Randomized Controlled Trial. J Clin Oncol. 2021. 39(33):3682–92. https://doi.org/10.1200/JCO.20.02530

38. Handayani S. The Relationship Between Clinical Stage and Survival of Cervical Cancer Patients at Dr. Wahidin Sudirohusodo General Hospital, Makassar. 2019. 1(2):93–100. https://ocs.unmul.ac.id/index.php/MJPH/article/view/3054

39. Muchtariza S, Aria Gusti, Masrizal Masrizal. Survival Rate of Cervical Cancer Patients Based on Clinical Stage at Andalas University Hospital 2019–2023. JIK Jurnal Ilmu Kesehatan. 2024. 8(2):370–5. http://dx.doi.org/10.33757/jik.v8i2.1118

40. Hafildah U, Karisma RDLN. Survival analysis in cervical cancer patients using Cox Proportional Hazard regression. 2021.

41. Purnami LA, et.al. The relationship between the characteristics of women of childbearing age (WUS) and cervical cancer. Jurnal Keperawatan Silampari. 2022. 6(1):400–8.

Downloads

Published

2026-03-31

Most read articles by the same author(s)