Research involving experimental animals be carried out following animal ethics and welfare. Experimental animals must be appropriately treated and minimizing the pain that might arise during the treatment. The utilization of experimental animals must be following local, national, and international regulations. The authors must make a statement, including the name of the ethical authority and the consent number; the trial is carried out in compliance with animal ethics and welfare.

Experiments should be carried out in accordance with the Guidelines laid down by the International Animal Ethics Committee or Institutional ethics committee and in accordance with local laws and regulations. All studies using animal subjects should include an explicit statement in the Material and Methods section identifying the review and ethics committee approval for each study (please provide ethical approval numbers), if applicable. Editors reserve the right to reject papers if there is doubt as to whether appropriate procedures have been used.