Alternate Day Fasting terhadap Berat Badan, dan Enzim Transaminase pada Tikus Putih Galur Sprague Dawley
DOI:
https://doi.org/10.22437/esehad.v5i1.35373Keywords:
Obesitas, Alternate_Day_Fasting, berat_badan, SGOT, SGPT, Obesity, body_weightAbstract
ABSTRACT
Background Obesity is a global epidemic problem that can increase the risk of metabolic syndrome and insulin resistance. Modification of diet and moderate exercise can control metabolism. Alternate Day Fasting is one of the intermittent fasting diet modifications where the day alternates between normal and fasting diets. When fasting can consume food substances 20-25% of total energy. Aim this research objective was to determine the effect of the Alternate Day Fasting diet on body weight, and liver function. Method this research is an experimental study on male Sprague Dawley rats aged 2-3 months, weighing 150-250 grams, and no anatomical abnormalities, which are divided into 2 groups, namely control (n = 10) and Alternate Day Fasting (n = 10). Results the Alternate Day Fasting can reduce body weight (mean = 197.5) compared to controls (mean = 253.6). There was no difference in blood glucose (Mann Whitney; p> 0.05), Serum Glutamic Oxaloacetate Transaminase (Mann Whitney; p> 0.05), Serum Glutamic Pyruvic Transaminase (Mann Whitney; p> 0.05) between the control group and the Alternate Day Fasting diet. Conclusion Alternate Day Fasting Diet can lose weight, and does not result in an increase in Serum Glutamic Oxaloacetic Transaminase and Serum Glutamic Pyruvic Transaminase.
Keywords: Obesity, Alternate_Day_Fasting, body_weight, SGOT, SGPT
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References
Ganesan K., Habboush Y, Sultan S. Intermittent Fasting: The Choice for a Healthier Lifestyle. Cureus. . 2018;10(7). http://doi: 10.7759/cureus.2947.
Putri Andi Yusran Fadilah, Decroli Eva, Nasrul Ellyza. Hubungan Derajat Obesitas dengan Kadar Gula Darah Puasa Pada Masyarakat Di Kelurahan Batung Bata dan Kelurahan Korong Gadang, Kota Padang. Jurnal Kesehatan Andalas .2015;4(3):707–711.
Tinsley G M, La Bounty P M. Effects of intermittent fasting on body composition and clinical health markers in human, Nutrition Reviews. 2015;73(10): 661–674. http://doi: 10.1093/nutrit/nuv041.
St-Onge, M. P. et al. Meal Timing and Frequency: Implications for Cardiovascular Disease Prevention: A Scientific Statement from the American Heart Association, Circulation. 2017; 135(9):. e96–e121. http://doi: 10.1161/CIR.0000000000000476.
Stockman MC, Thomas D, Burke J, Apovian CM. Intermittent Fasting: Is the Wait Worth the Weight?". Current Obesity Reports (Review). 2018;7 (2): 172–185.
Patterson, R. E. et al. (5AD).Intermittent Fasting And Human Metabolic Health Ruth. J Acad Nutr Diet. 2017; 150(2):137–143.http:// doi: 10.1001/jamasurg.2014.1086.Feasibility.
Templeman, I. et al. Intermittent fasting, energy balance and associated health outcomes in adults: Study protocol for a randomised controlled trial’, Trials. Trials. 2018;19(1):1–11. http://doi: 10.1186/s13063-018-2451-8.
Jane, L. et al. Intermittent fasting interventions for the treatment of overweight and obesity in adults aged 18 years and over: a systematic review protocol. JBI database of systematic reviews and implementation reports. 2015;13(10):60–68. http://doi: 10.11124/jbisrir-2015-2363.
Vilar-Gomez, E. et al. Weight loss through lifestyle modification significantly reduces features of nonalcoholic steatohepatitis. Gastroenterology. 2015:149(2);. 367-378.e5. http://doi: 10.1053/j.gastro.2015.04.005.
Hall P, Cash J. What is the real function of the liver “function” tests?: Discovery Service for Endeavour College of Natural Health Library. Ulster Medical Journal, 2012;81(1):30–36. http:// www.ebscohost.com.
Alfin R, Busjra B, Azzam R. Pengaruh Puasa Ramadhan terhadap Kadar Gula Darah pada Pasien Diabetes Mellitus Tipe II. J Telenursing. 2019;1(1):191– 204.
Soeters MR, Lammers NM, Dubbelhuis PF, Ackermans MT, Jonkers-Schuitema CF, Fliers E, et al. Intermittent Fasting Does Not Affect Whole-body Glucose, Lipid, or Protein Metabolism. Am J Clin Nutr. 2009;90(5):1244–51.
Agung, A. et al. The Activities of Alanine Aminotransferase and Aspartate Aminotransferase Enzymes in Male White Rats Treated With Extract Areca Nut Treatment’, Buletin Veteriner Udayana.2017;9(2);132–138.http:// doi: 10.21531/bulvet.2017.9.2.132
