This journal was founded in 2015 and Winda Dwi Kartika as the first editor in chief.

The first system that used is OJS 2 and author sent the article by email to editor.

In the late year of 2016 until beginning 2017 was transition phase of this Journal because in that year the system was changed to OJS 3. In this period, editorial teams still using email as corresponding media to the authors.

In 2018 this journal has new editor in chief, Ashif Irvan Yusuf.

In 2019, Bio-Site Journal changed article format and template. There are few changes such as addition Biologi dan Sains Terapan in the journal name, abstract using 2 languages (bahasa Indonesia and English), no more 2-column format of article. And it's also added the information about format and template changed in author guideline.