Skrining Triterpenoid dan Formulasi Granul dari Ekstrak Daun Mengkudu (Morinda Citrifolia L.) sebagai Neuroprotektor pada Perokok

  • Dhigna Luthfiyani Citra Pradana Fakultas Sains dan Teknologi, Universitas Jambi
Keywords: Granuls, Morinda citrifolia, Triterpenoid

Abstract

The objective of this research was triterpenoids screening and made granules formulafrom Morindacitrifolia leaf extract as neuroprotector for smoker. Morinda citrifolia leaf extract was made by maceration using 70% ethanol. The granules of Morinda citrifolia leaf extract was composed by 3 formulas containing 10% leaf extract of Morinda citrifolia and with different levels of manitol (20% F I, F II 25%, 30%). All of formulas comply the qualification of affects fixed corner and granules flow time that base on Farmakope Indonesia. The variation of manitol concentration significantly affects fixed corner and granules flow time. The greater level of mannitol concentration 20% to 30%produced fixed corner and granules flow time of the granulesare greater.

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References

1. Anonim, 1979, Farmakope edisi III,6-9, 915,
2. Departemen Kesehatan Indonesia, Jakarta. Anonim, 1985, Cara Pembuatan Simplisia, 4-15, Departemen Kesehatan Republik Indonesia, Jakarta.
3. Anonim, 1986, Sediaan Galenik, 4-21, Departemen kesehatan Republik Indonesia, Jakarta.
4. Anonim, 1995, Farmakope edisi IV, 4-7, 489, 515, 519, 551, 713, 771, 999,Departemen Kesehatan Indonesia, Jakarta.
5. Anonim, 2010, Efek Rokok pada Sistem Saraf. http://www.keluargadakwah.co m/artikel/efek-rokok-padasistem- saraf/, diakses tanggal 18 Januari 2011.
6. Banker, G.S., dan Anderson, N.R., 1986, Tablet, dalam Lacman, L., Liebermen, H.A., Kanig, J.L., Tablet In The Theory and Practice of Industrial Pharmacy, Ed III, Diterjemahkan oleh Siti Suryatmi, 648, 653, 662,684, 692-707, Penerbit Universitas Indonesia, Jakarta.
7. Fudholi, A., 2001, Teknologi dan Formulasi Sediaan Obat Bahan Alam dan Permasalahannya, Pharmacon, 2,(1), 25-33, Farmasi UMS, Surakarta.
8. Harborne, J. B., 1987, MetodeFitokimiaPenuntun Cara Modern MenganalisisTumbuhan, 47-54, ITB, Bandung.
9. Lu , J., Dong-mei, W., Yuan-lin, Z., Bin, H., Zi-feng, Z., Qin, Y., Chanmin, L., Qun, S., dan Yong-jian, W., 2010, Ursolic Acid Attenuates D-Galactose- Induced Inflammatory Response in Mouse Prefrontal Cortex through Inhibiting AGEs/RAGE/NF-kB Pathway Activation, Cerebral Cortex, doi:10.1093/cercor/bhq002.cer cor.oxfordjournals.org.
10. Palu, A.K., Bing-Nan, Z., Brett, J.W., Claude, J.J., 2006, Nicotinic Acethylcoline Receptor Antagonist,Pub.No.: US 2006/0280818 A1
11. Stachowiak, J., 2009, Basic Multiple Sclerosis Information. http://ms.about.com/od/multi plesclerosis101/f/alzheimers_ ms_link.htm, diakses tanggal 18 Januari 2011.
12. Sulaiman, T.N.S., 2007, Teknologi dan Sediaan Tablet, 30, 85, 149- 156, Pustaka Laboratorium Teknologi Sediaan Farmasi Fakultas Farmasi Universitas Gadjah Mada, Yogyakarta.
13. Ulfah, N., 2009, Ancaman Penyakit Saraf untuk Perokok. http://www.detikhealth.com/re ad/2009/09/01/101617/11937 17/763/ancaman-penyakitsaraf- untuk-perokok, diakses tanggal 18 Januari 2011.
14. Widayati, E., 2010,Jumlah Perokok Indonesia Terbesar Ketiga Dunia,http://terbaru2010.com /jumlah-perokok-perempuanmeningkat. html, diakses tanggal 30 November 2010.
How to Cite
Pradana, D. (1). Skrining Triterpenoid dan Formulasi Granul dari Ekstrak Daun Mengkudu (Morinda Citrifolia L.) sebagai Neuroprotektor pada Perokok. BIO-SITE |Biologi Dan Sains Terapan, 2(2). Retrieved from https://online-journal.unja.ac.id/index.php/BST/article/view/3414
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