Perbedaan Tingkat Depresi Pasien Kanker Sebelum dan Sesudah Kemoterapi Pertama

Authors

  • Muhamad Zulfatul A'la Fakultas Keperawatan, Universitas Jember, Jember
  • Puji Arini Fakultas Keperawatan, Universitas Jember, Jember
  • Wantiyah Wantiyah Fakultas Keperawatan, Universitas Jember, Jember
  • Baskoro Setioputro Fakultas Keperawatan, Universitas Jember, Jember
  • Akhmad Zainur Ridla Fakultas Keperawatan, Universitas Jember, Jember

DOI:

https://doi.org/10.22437/jini.v4i2.27472

Keywords:

cancer patients, depression, first chemotherapy

Abstract

Cancer is one of the main causes of death in the world. The most common cancer treatment is chemotherapy. Chemotherapy in its implementation has a physical and psychological impact on cancer patients. This study aims to determine the differences in depression in cancer patients before and after the first chemotherapy at Baladhika Husada Hospital, Jember. It was a longitudinal study with a comparative design. A total of 39 respondents were recruited using purposive sampling. Respondents before chemotherapy were 39 patients and after chemotherapy there were 39 patients. Beck Depression Inventory II with 21 statement items is utilized as a measuring tool to see the level of depression. Data were analyzed using the Wilcoxon test with a significance level <0.05. The results showed that 3 patients experienced a decrease, 5 patients did not change, and 31 patients experienced an increase in depression after 7 days of first chemotherapy. The Wilcoxon test showed no difference in depression in cancer patients before and after the first chemotherapy (p = 0.000; Z = -4.574). The conclusion of this study showed that there were differences in depression in cancer patients before and seven days after the first chemotherapy at Baladhika Husada Hospital, Jember. This difference is influenced by the side effects of chemotherapy that cause depression in cancer patients. Further research recommends exploring at the factors that influence depression after the first chemotherapy and subsequent chemotherapy.

ABSTRAK

Kanker adalah salah satu penyebab utama kematian di dunia. Perawatan kanker yang paling umum adalah kemoterapi. Kemoterapi dalam implementasinya memiliki dampak fisik dan psikologis pada pasien kanker. Penelitian ini bertujuan untuk mengetahui perbedaan depresi pada pasien kanker sebelum dan sesudah kemoterapi pertama di rumah sakit Baladhika Husada, Jember. Ini adalah studi longitudinal dengan desain komparatif. Sebanyak 39 responden direkrut dengan menggunakan purposive sampling. Responden sebelum kemoterapi adalah 39 pasien dan sesudah kemoterapi ada 39 pasien. Beck Depression Inventory II dengan 21 item pernyataan digunakan sebagai alat ukur untuk melihat tingkat depresi. Data dianalisis menggunakan uji wilcoxon dengan tingkat signifikansi <0,05. Hasil penelitian menunjukkan bahwa 3 pasien mengalami penurunan, 5 pasien tidak berubah, dan 31 pasien mengalami peningkatan depresi sesudah 7 hari pasca kemoterapi pertama. Uji Wilcoxon menunjukkan ada perbedaan dalam depresi pada pasien kanker sebelum dan sesudah kemoterapi pertama (p = < 0,01; Z = -4,574). Kesimpulan dari penelitian ini menunjukkan bahwa ada perbedaan depresi pada pasien kanker sebelum dan tujuh hari sesudah kemoterapi pertama di Rumah Sakit Baladhika Husada Jember. Perbedaan ini dipengaruhi oleh efek samping kemoterapi yang menyebabkan depresi pada pasien kanker Penelitian selanjutnya merekomendasikan untuk melihat faktor-faktor yang mempengaruhi depresi pasca kemoterapi pertama maupun kemoterapi selanjutnya.

Kata Kunci: Depresi, Pasien Kanker, Kemoterapi Pertama

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References

Ambarwati, W. N., & Wardani, E. K. (2014). Efek Samping Kemoterapi Secara Fisik Pasien Penderita Kanker Servik.Jurnal Universitas Muhammadiyah Semarang, 97–106.

Apriansyah, M.A., Putranto, R., Salim, E.M., Shatri, H. (2016). Korelasi Tingkat Depresi dengan Kadar Tumor Necrosis Factor-Alpha pada Penderita Asma Bronkial Tidak Terkontrol. Jurnal Penyakit Dalam Indonesia, 3(2), 74-80.

Baqutayan, S. M. S. (2012). Review Article The Effect of Anxiety on Breast Cancer Patients. Indian Journal of Psychological Medicine |, 34(2), 119. https://doi.org/10.4103/0253-7176.101774

Baraki, A. G., Tessema, G. M., & Demeke, E. A. (2020). High burden of depression among cancer patients on chemotherapy in University of Gondar comprehensive hospital and Felege Hiwot referral hospital, Northwest Ethiopia. PLoS ONE, 15(8 August 2020), 1–10. https://doi.org/10.1371/journal.pone.0237837

Bower, J.E., Ganz, P.A., Irwin, M.R., Kwan, L., Breen, E.C., & Cole, S.W. (2015). Inflammation and Behavioral Symptoms After Breast Cancer Treatment: Do Fatigue, Depression, and Sleep Disturbance Share a Common Underlying Mechanism?. Journal of Clinical Oncology, 29(26). https://doi.org/10.1200/JCO.2011.36.1154

Bulechek, G. M., Butcher, H., Dochterman, J., & Wagner, C. (2016). Nursing Interventions Classification (NIC) (Edisi 6). Elsevier Ltd.

Cheng, K. K. F., & Yeung, R. M. W. (2012). Impact of mood disturbance , sleep disturbance , fatigue and pain among patients receiving cancer therapy. European Journal of Cancer Care, 22(1). https://doi.org/10.1111/j.1365-2354.2012.01372.x

Chintamani, Gogne, A., Khandelwal, R., Tandon, M., Jain, S., Kumar, Y., Narayan, N., Bamal, R., Srivinas, S., & Saxena, S. (2011). The correlation of anxiety and depression levels with response to neoadjuvant chemotherapy in patients with breast cancer. Journal of the Royal Society of Medicine, 2(3), 1–6.

Desen, W. (2012). Buku Ajar Onkologi Kinis. Balai Penerbit FKUI.

Effendy, C., Vissers, K., Osse, B. H. P., Tejawinata, S., & Ecu, P. (2015). Comparison of Problems and Unmet Needs of Patients with Advanced Cancer in a European Country and an Asian Country. Pain Practice, 15(5), 433–440.

Elsea, C. R., Kneiss, J. A., & Wood, L. J. (2015). Induction of IL-6 by Cytotoxic Chemotherapy Is Associated With Loss of Lean Body and Fat Mass in Tumor-free Female Mice. Biological Research for Nursing, 17(5), 549–557. https://doi.org/10.1177/1099800414558087

Fata, U. H. (2015). The Correlation of Anxiety and Depression with Fatigue in Cancer Patient Undergoing Chemotherapy. Jurnal Ners Dan Kebidanan (Journal of Ners and Midwifery), 2(1), 095–102. https://doi.org/10.26699/jnk.v2i1.ART.p095-102

Ginting, H., Näring, G., Van Der Veld, W. M., Srisayekti, W., & Becker, E. S. (2013). Validating the Beck Depression Inventory-II in Indonesia’s general population and coronary heart disease patients. International Journal of Clinical and Health Psychology, 13(3), 235–242. https://doi.org/10.1016/S1697-2600(13)70028-0

Howren, M. B., Lamkin, D. M., & Suls, J. (2009). Associations of Depression With C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis. Psycosomatic Medicine, 71, 171–186. https://doi.org/10.1097/PSY.0b013e3181907c1b

Hurst, M. (2015). Belajar Mudah Keperawatan Medikal-Bedah. EGC.

Janelsins, M.C., Mustian, K.M., Palesh, O.G., Mohile, S.G., Katz, A.W., Williams, J.P., & Morrow, G.R. (2012). Differential expression of cytokines in breast cancer patients receiving different chemotherapies: implications for cognitive impairment research. Support Care Cancer, 20, 831–839. https://doi.org/10.1007/s00520-011-1158-0

Jenkins, T. A., Nguyen, J. C. D., Polglaze, K. E., & Bertrand, P. P. (2016). Influence of Tryptophan and Serotonin on Mood and Cognition with a Possible Role of the Gut-Brain Axis. Nutrients, 8(56), 1–15. https://doi.org/10.3390/nu8010056

Jim, H. S. L., Small, B., Faul, L. A., Franzen, J., Apte, S., & Jacobsen, P. B. (2011). Fatigue, Depression, Sleep, and Activity During Chemotherapy: Daily and Intraday Variation and Relationships Among Symptom Changes. The Society of Behavioral Medicine, 42, 321–333. https://doi.org/10.1007/s12160-011-9294-9

Kamen, B. A. (2010). Clinical Aspects of Pharmacogenetics of Pain and Co- Morbidities of Emotional Distress. Asian Pacific Journal of Cancer Prevention, 11, 2008–2011.

Kemenkes RI. (2015). Pedoman Nasional Pelayanan Paliatif Kanker.

Kementerian Kesehatan RI Badan Penelitian dan Pengembangan. (2018). Hasil Utama Riset Kesehatan Dasar. Kementrian Kesehatan Republik Indonesia, 1–100. http://www.depkes.go.id/resources/download/info-terkini/hasil-riskesdas-2018.pdf

Lemone, P., Burke, K. M., & Bauldoff, G. (2015). Buku Ajar Keperawatan Medikal Bedah (5th ed.). EGC.

Maneeton, B., Maneeton, N., & Mahathep, P. (2012). Prevalence of Depression and Its Correlations: a Cross-sectional Study in Thai Cancer Patients. Asian Pacific Journal of Cancer Prevention, 13, 2039–2043.

Miranda, D. O., Aparecida, T., Lima, S. De, Azevedo, L. R., Feres, O., Joaquim, J., & Pereira-da-silva, G. (2014). Proinflammatory Cytokines Correlate with Depression and Anxiety in Colorectal Cancer Patients. BioMed Research International, 2014(5).

Mishra, N., & Dwivedi, R. (2015). Study of Depression in Women with Cevical and Breast Cancer. Journal of Evolution of Medical and Dental Sciences Scopus, 4(12), 1936–1943. https://doi.org/10.14260/jemds/2015/281

Neilson, K., Pollard, A., Boonzaier, A., Corry, J., Castle, D., Smith, D., Trauer, T., & Couper, J. (2013). A longitudinal study of distress ( depression and anxiety ) up to 18 months after radiotherapy for head and neck cancer. Psycho Onkologi, 22(8), 1843–1848.

Ponticelli, E., Clari, M., Frigerio, S., De Clemente, A., Bergese, I., Scavino, E., Bernardini, A., & Sacerdote, C. (2017). Dysgeusia and health-related quality of life of cancer patients receiving chemotherapy: A cross-sectional study. European Journal of Cancer Care, 26(2). https://doi.org/10.1111/ecc.12633

Rapoport, B. L. (2017). Delayed Chemotherapy-Induced Nausea and Vomiting: Pathogenesis, Incidence, and Current Management. Frontiers in Pharmacology, 8, 1-10./fphar.2017.00019

Saligan, L. N., Olson, K., Filler, K., Larkin, D., Cramp, F., Sriram, Y., Escalante, C. P., Giglio, A., Kober, K. M., Kamath, J., & Palesh, O. (2015). The biology of cancer-related fatigue: a review of the literature: Support Care Cancer, 8, 2461. https://doi.org/10.1007/s00520-015-2763-0

Sari, M., Dewi, Y. I., & Utami, A. (2012). Hubungan Dukungan Keluarga terhadap Motivasi Pasien Kanker Payudara dalam Menjalani Kemoterapi di Ruang Cendrawasih I RSUD Arifin Achmad Provinsi Riau. Jurnal Ners Indonesia, 2(2).

Sonia, G., Arifin, H., & Murni, A. W. (2014). MENGALAMI ANSIETAS DAN DEPRESI. MKA, 37(1), 32–37.

Souza, B.F. De, Elisa, A., Camargo, B. De, & Miasso, A.I. (2014). Women with breast cancer taking chemoterapy: depression symptoms and treatment adherence. Revista Latino-Americana de Enfermagem, 22(5), 866–873. https://doi.org/10.1590/0104-1169.3564.2491

Tung, H., Chao, T., Lin, Y., Wu, S., Lee, H., Ching, C., Hung, K., & Lin, T. (2016). Depression , Fatigue , and QoL in Colorectal Cancer Patients During and After Treatment. Western Journal of Nursing Research, 162, 1–16. https://doi.org/10.1177/0193945916630256

Vyas, D., Laput, G., & Vyas, A. K. (2014). Chemotherapy-enhanced inflammation may lead to the failure of therapy and metastasis. Onco Targets and Therapy, 7, 1015–1023.

WHO. (2018). Latest Global Cancer Data: Cancer Burden Rises to 18.1 Million New Nases and 9.6 Million Cancer Deaths in 2018. International Agency for Research on Cancer. 13-15.

World Health Organization (WHO). (2020). WHO Report on Cancer. World Health Organization (WHO).

Yusof, S., Zakaria, F. N., Hashim, N. K., & Dasiman, R. (2016). Depressive Symptoms among Cancer Patients Undergoing Chemotherapy. Procedia - Social and Behavioral Sciences, 234, 185–192. https://doi.org/10.1016/j.sbspro.2016.10.233

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Published

2023-11-30

How to Cite

A’la, M. Z., Arini, P., Wantiyah, W., Setioputro, B., & Ridla, A. Z. (2023). Perbedaan Tingkat Depresi Pasien Kanker Sebelum dan Sesudah Kemoterapi Pertama . Jurnal Ilmiah Ners Indonesia, 4(2), 145-157. https://doi.org/10.22437/jini.v4i2.27472